I'll have to play that one. Thanks for the info.

 

Fruit has fructose. I didn't see the video yet but I'm guess people are getting scads more in processed foods.

 

Yes, fruit has fructose, but modern fruits are bred to be sweeter and larger than "natural" in the wild. MUCH more fructose.

Fruit juices overload you with fructose, too.

 

Before anyone panics, a little basic biochemistry-- fructose and glucose are essentially interchangeable molecules. One is quickly & easily converted to the other and back again in any given metabolic situation.as required by the enzyme hexose isomerase....Sucrose (regular table sugar) is a dissaccharide made up of one fructose and one glucose stuck together....Corn makes hexoses in a ratio of 55 fructose to 45 glucose. It does not make sucrose. It's cheaper to collect fructose & glucose from corn than to collect & process sucrose from cane and beets.

There's a good deal of research published about how glucose & fructose are handled differently in the body..It's all BS with little practical implications. (Would you rather get crushed by a ton of rock or a ton of feathers?)

Uric acid-- involved in the metabolism of nucleic acid. People with gout have a defect in that metabolism involving the enzyme xanthine oxidase. Uric acid is not cleared from the circulation as quickly in gout and may precipitaye out in joint fluid and urine. Build uo of the crystals in the kidney can lead to renal failure. (Conversely, people with severe renal failure can have problems excreting uric acid.)

The association of elevated uric acid levels and heart disease is controversial-- it's difficult to separate the fact that CAD goes up with age, as does RF and uric acid levels-- are they aoll related independently to aging or is one causative of the other?

Another example of "nobody will pay to hear the simple truth" unless we imply a reason to panic.

 

So, your saying...getting old sucks. I agree!!

 

So, are you shooting down the theory that elevated fructose isn't good for your body?

Let me know, please. If you are going to the poo-pooing every interesting thing that I post (for example, new research about how nutrition has an impact on our health), I won't post any more of those types of topics.

I wouldn't have minded a simple rebuttal or discussion, but implying that I am trying to panic anyone or that I am posting BS wasn't nice.

 

So, are you shooting down the theory that elevated fructose isn't good for your body?

Let me know, please. If you are going to the poo-pooing every interesting thing that I post (for example, new research about how nutrition has an impact on our health), I won't post any more of those types of topics.

I wouldn't have minded a simple rebuttal or discussion, but implying that I am trying to panic anyone or that I am posting BS wasn't nice.

I'm always amazed at your knowledge base, but you still probably don't have enough expertise to critically analyze medical lit....I'm not calling you out for posting BS...I'm just pointing out that it's BS.

If you have a high uric acid level, you should avoid fructose.
Uric acid is also formed in the body from the breakdown of purines. Foods rich in purines include high-fat meat and sausages, ham, bacon, oily fish, canned fish, crustaceans, legumes.

With just HS Bio under our belts, we should be able to deduce that this stuff doesn't make sense-->

Yes, ueic acid is one of the intermediates in the synthesis of purines...Purines & Pyimidines are the two basic building blocks of DNA and RNA. They occur roughly in a 50:50 mix in each cell...Why would one cell type have any more than another?...

Look at this list of "purine content" of various foods-- some have much more than others, BUT-- they are listed according to "mg uric acid/ 100 gm"-- https://elevatehealthaz.com/wp-content/Purine Table.pdf

Eg-- sardines are high at 480 and brewer's yest even higher at 1810 (Wow!!!)-- but how many of us drink a qtr lb of yeast in beer at one sitting, or a qtr lb of sardines at a time?...Beef is pretty low at 110, but it's easy to eat a Quarter Pounder or two at one sitting, so you're getting way more purine than eating a few ounces of sardines or drinking a couple beers.....and at any rate, it's not how much purine you're eating. It's how your body handles it.--For most of us, we can handle all we can get without any problems. For those with other genotypes (like gout) we can saturate our systems and have problems.

All cells have basiucally the same nucleic acid content, ergo, the same purine content. How much purine you take in has more to do with how may cells you eat, not how much purine is in each cell.

In reards fructose-- let me repeat-- fructose and glucose are immediately interchangeable in any cell biochemical process-- Your body doesn't "know" which form you ate. Any reserch suggesting otherwise,if scrutinized properly, will show any difference seen in a test tube has no real -life meaning....It's like those tall plastic adverizing men blowing around, changing shape continually---at any given moment the arms and legs may be pointed in differing directions, but it's all the same plastic guy.

 

Uric acid elevation in your blood has been recognized as a signal that your kidneys aren't able to eliminate it from your blood stream. (kidney failure symptom)

Elevated uric acid is now being recognized as harmful in other significant ways.

1. Increased obesity due to an effect on our cells.
2. Increased glucose level (very often a factor of Type II Diabetes)
3. Gout was known as uric acid crystalizing in the joints. It is extremely painful. Now we have learned that the uric acid can form small crystals in the blood vessels that cause damage in other parts of the body.
4. Increased high blood pressure.
5. The doctors are in the midst of determining that increased uric acid may
factor in Alzheimer's.

Why are we seeing so many folks with elevated uric acid?

Fructose. The Standard American Diet (processed foods) includes fructose used for a cheap sweetener. I am going to listed to the podcast again about the increase rate, but suffice it to say that we need to be reading labels.

Here's a 15 minute podcast about fructose and uric acid. It's a week bit technical, but definitely worth a listen. Don't be put off by the doctor's catchy title for his new book.

Mapping Uric Acid with Dr. David Perlmutter #293

When we hear about problems with uric acid, we tend to think about gout. In this episode, I’m joined by renowned neurologist Dr. David Perlmutter to discuss new research that shows the correlation between uric acid and today’s common chronic conditions such as Type 2 diabetes, CVD and other...

www.fxnutrition.com

If you have a high uric acid level, you should avoid fructose.
Uric acid is also formed in the body from the breakdown of purines. Foods rich in purines include high-fat meat and sausages, ham, bacon, oily fish, canned fish, crustaceans, legumes.

 

Uric acid is formed by purines, alcohol, and fructose.

Unless Doc thinks differently, I guess.

Source: High Uric Acid Level: Causes, Risks, Treatment, Prevention

• Seafood (especially salmon, shrimp, lobster and sardines)
• Red meat
• Organ meats like liver
• Food and drinks with high fructose corn syrup, and alcohol (especially beer, including non-alcoholic beer)

 

It would be great if folks took 15 minutes to listen to the podcast.

 

Please continue to post what interests you.

 

i eat a can of sardines every day. i thought that was supposed to be good for us. better stop that. Georgia

 

Only if you are HAVING uric acid/gout problems. If not, enjoy!!

 

Thanks for that link Alice. I never knew fructose was a trigger too.
I battled gout for quite a few years till I adjusted my diet. No alcohol anymore, and some red meats would set me off bad. Strangely, I can eat hamburgers every day of the week, but a beef roast, corned beef, ect I have to be very careful on eating still. The first time I had a flare up I thought I broke my foot, but couldn’t figure out how it happened.

 

My neighbor is 69 and it feels the same to him. At first sign, his wife makes up some potion with, let me think, tumeric, garlic, cherries, maybe apple cider vinegar, pineapple and maybe a few other items in the spice rack. Mixes it with tea I believe, and it seems to clear up in a few days.

 

He says his usually starts in front inbetween a couple of toes and then gets larger and more intense and moves around his foot till it goes away.
He is about 6'3 and 240lbs and loves his meat.

 

Im left handed, it would always hit my left foot, around the big toe and ball of my foot. Then started getting it in my left wrist and left middle finger. I remember walking around at work with my hand swollen and unusable. I told one of my helpers he was going to have to do his job, and the physical part of my job, as it would feel like it was literally broken.

 

I almost forgot, a heavy dose of Ibuprofen washed down with whiskey or a nonalcholic beverage.

 

i did have it once or twice. didn't know what the heck it was until i researched it. it was lamb doing it for me. i eat very little of it now although it's my favorite meat. i had it along the side of my ear. little crystals. haven't had it for years. i do take apple cider vinegar every day. ~Georgia

 

Cherries and cherry juice (unsweetened)

From a research article:

"Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy."

Is there a role for cherries in the management of gout?

Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, leading ...

www.ncbi.nlm.nih.gov

 

Cherries and cherry juice (unsweetened)

From a research article:

"Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy."

Is there a role for cherries in the management of gout?

Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, leading ...

www.ncbi.nlm.nih.gov

I've treated many pts with gout who've insisted on religiously using cherry juice. While we have no idea how many acute attacks they would have had had they not used the juice, they still got their share of acute attacks. They still need their Indomethicin or prednisone when they get an attack.

How many willow trees would you have to kill to get enough bark to chew on to treat a headache that could easily be stopped with one aspirin tablet?...It's no secret that plants make chemicals that have medicinal effects...The probem is you can't eat enough of the herbs & spices to equal the concentration of the commercially isolated preps....How many loaves of moldy bread equals one PCN tab?

If you have gout, take the appropriate meds...If you don't have gout, you don't have to worry about uric acid. It's a non-problem for you.

 

Kidneys are important. Make a bad bow shot on a deer, and nick a renal artery with a broadhead, and they bleed out just as quick as with a heart shot.The kidney is a filter. Run a hydraulic system with a clogged filter and see what happens to a piece of equipment. Well, your blood pumps through a hydraulic system. Clog the filter, blow the pump. The good thing is that we don't have to change our filters, because we can flush them with solvent. Best solvent for this purpose is water. When we get older, for some reason, we have to pee more often, and sometimes our urine leaks out, and all sorts of nasty things. It might even hurt our joints to get up to use the bathroom. There once was a time that I could sleep through an entire night without going to the potty. Natural human inclination, when faced with inconvenience, is to avoid things that cause inconvenience. A lot of people, as they get older, don't drink enough, because they don't want to go to the bathroom every five minutes.

 

Yes, kidneys are critical to survival. My husband has my left kidney.

Urinary incontinence is a different thing. Sorry if you are suffering from that. Have you seen a urologist?

 

@Alice In TX/MO, keep posting topics you think are interesting. Those who want to follow along will do so, despite someone crapping on your parade.

I haven't had a chance to listen to the video but I find the discussion very interesting.

 

I just listened to the podcast. It is extremely interesting to think that Alzheimer's and some other conditions could be prevented just by drinking more water. Not exactly what was said in the program but it was broadly hinted that reducing purines before they can build up and do damage is likely a preventive measure. The best way to reduce purines is to flush them out of the system by drinking more water. At least that was what I got from the program.

 

I didn’t read your whole post, Doc, as I have an early appointment.

You have NO idea about my education or experience.

 

You didn’t read the referenced article, apparently.

 

I always loved it when a pt brought me something out of the National Enquirer.

 

I am sure you did.

Your implication is offensive.
If your forum manners are similar to your bedside manner, I pity your patients.

 

The article (results of a study) about cherries was published on the nih.gov website. Are you equating that with the National Inquirer?

 

I don't how old Doc is, but the science/research/knowledge base changes. I am looking at new research from knowledgeable sources. He didn't read it, obviously, so he didn't know it was recent and from the NIH.

Unfortunately for other folks (both here and in real life), I'm a retired English teacher and debate coach. WORDS MEAN THINGS, and when he starts his high horse routine, I get miffed.

As I said, he could have presented his ideas in a more polite manner. Just because he used to be a practicing doctor doesn't mean he's an expert on everything.

 

As I said, he could have presented his ideas in a more polite manner. Just because he used to be a practicing doctor doesn't mean he's an expert on everything.

View attachment 106024

I'd be ok with Milburn Stone or DeForest Kelly as my primary physician.
They seemed to have saved anyone not shot with an arrow or a phaser and usually had whiskey on hand and I'm good with that.