We have a sick male goat (wether) about 4 years old. He is normally extremely robust (biggest goat we have - at nearly 200 pounds he is almost as large as a pony!) He does have a history of suffering the occasional episode of polioencephalomalcia or "star-gazing" syndrome (usually seasonal just - about this time of the year when they start back on hay after a summer of free browsing in the woods). He has had this twice before, as has his sire and his twin sister. Of our 14 goats, (all pets) these 3 are the only ones to suffer this condition, so I'm wondering if it is hereditary (but that isn't my question, so I'll try not to get side-tracked). What has me worried is that usually when this happens a quick dose of Thiamine (followed by antibiotic treatment - Oxytetracycline - for 3 days; and further daily doses of thiamine for 1 week) does the trick. Almost always, the Thiamine will bring them back to near normal within 24 hours, and they are going full speed within 3 days. But this time, he doesn't seem to be getting better. Its been about 1 week since we gave him the first dose of Thiamine (and we caught this very early - within a couple of hours of his becoming symtomatic) but he still seems a bit dazed. He no longer has the trembling and muscular problems associated with polioencephalomalcia, and he gets up and walks around a bit, but he just looks sick - nose is runny; eyes kind of "rheummy" and he won't eat. He seems to have trouble swallowing, and has no appetite at all. He just sort of sits or stands and looks around in a really apathetic way - like he feels too bad to care about anything. Once in awhile he will vocalize - a kind of sigh or moan, but in a really half-hearted way. He is normally a very loving goat - loves to be petted and talked to (he was hand raised by us when his momma rejected him) so he responds to our sitting with him (we have him in the utility room with straw and a heat lamp right now) and talking to him, but no matter what we offer him to eat, he just won't take it. I'm really worried about him and just can't figure this out. Is it possible that the polioencephalomalcia has coincidentally occurred along with a virus of some sort? Could he have the flu? If so, or if there is some other possibility, what can be done to help him? Poor guy looks so miserable and he is starting to get thin. Any suggestions?