I live full time in a fifth wheel, though it's parked and not going anywhere.
Consider cold weather. If you end up stuck somewhere in winter, do you have what you'll need to get through? Most campers are NOT designed for true cold, even the less expensive "four seasons" type rigs. Even if you can baby a poorly designed trailer through freezing temps, you'll spend a ton on propane. (Mine sails through winter easily, but it's actually, truly, designed for cold weather. Little details matter, like a propane furnace that vents the moisture outside, and heated compartments for the wastewater tanks -- a pyramid of poo is annoying enough to deal with, without it being a frozen pyramid of poo.)
Also, if you plan to do canning on the road, I'd suggest that you get an outside propane burner and extra tanks for it. Remember that you need to haul all your gas with you. Also, most campers have tiny kitchens, with midget sized appliances -- I'm pretty sure my pressure canner wouldn't fit on the range in my kitchen, and even if it did, the burners probably wouldn't support the weight.
(While you're at it, if you plan to can or bake on the road, get yourself a GPS that tells altitude, so you can adjust cooking times accordingly.)