I swear by mega-doses of timed-release Vitamin C and, more recently, wild oregano oil. The combination, taken for about a week, has for me reliably aborted colds and flu time if taken soon after the first telltale signs that "it's got me" have appeared. Wild oregano oil is not cheap (nor easy to find), but the expense pales in comparison to the cost of being out of commission for the better part of a week.